Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis

Background and Aim: There are various studies on the inflammatory pathogenesis of nasal polyposis (NP). It has been suggested that discoidin domain receptor-1 (DDR1) and collagen type 4A (COL4A) have a role in formation of inflammatory responses in the tissue microenvironment. The aim of the study was to study the expressions of DDR1 and COL4A in NP, and nasal mucosa.

Materials and Methods: This randomized, prospective, controlled clinical study was conducted on 17 patients’ NP tissue and 24 subjects’ inferior nasal turbinate. DDR1 and COL4A expressions were determined by quantitative realtime PCR. Histopathologic examinations were also carried out. Protein levels of the samples were determined using ELISA. The associations between the parameters were explored.

Results: DDR1 and COL4A transcripts were found at similar levels in all of the samples. There were correlations between DDR1 and COL4A mRNA levels in both the NP and control groups. There was also a negative correlation between extracellular edema and COL4A protein levels in NP.

Conclusion: To our knowledge, this is the first study to report DDR1 expression in NP tissue. We did not find any significant differences between NP and inferior nasal turbinate in terms of expressions of DDR1 and COL4A. Prospective studies with large populations should be planned for understanding DDR1 role in NP.

Cite this article as: Turkoglu Babakurban S, Ozbal Koc A, Korkmaz Y, et al. Expression of Discoidin Domain Receptor 1 and Collagen Type IV Alpha in Nasal Polyposis. Eur J Rhinol Allergy. 2021;4(2):53-57.