The Effect of Eosinophilia Levels on the Radiological Severity of the Disease in Patients with a Nasal Polyp

Objective: In recent years, a different subtype, characterized by eosinophilia infiltration that is associated with T-helper cell type 2 (Th2) inflammation is known to worsen disease prognosis in patients with a nasal polyp. We aimed to assess the correlation of serum and tissue eosinophil levels and the radiological severity of the disease in our own patient group.

Material and Methods: Total 201 patients, including 131 men and 70 women who had undergone endoscopic sinus surgery for nasal polyp from 2013 to 2017 at the Aydın Adnan Menderes University Hospital were enrolled in our study. The eosinophil rates in the preoperative whole blood hemogram examinations and the rates of eosinophils in surgical pathologies were compared; the paranasal sinus computed tomography (CT) sections were evaluated as per the Lund-Mackey score and Kennedy osteitis score (KOS). Osteitis was scored radiologically as per the KOS systems. As per the tissue eosinophil count, more patients had an eosinophil count >10 eosinophil count/HPF (large magnification; 400×) and fewer had eosinophil count ≤10 eosinophil/HPF count.

Results: The Lund-Mackey scores were significantly higher in those with high eosinophil levels in the pathological specimens. The KOS were also found to be high in patients with high Lund-Mackey scores. In patients with higher eosinophil levels in the blood sample, the tissue eosinophil value in pathology samples was also high.

Conclusion: In patients with eosinophilia in the tissue or blood, the radiological prevalence and the osteitis scores of chronic sinusitis are expected to be high.

Cite this article as: Yıldırım FN, Akar YC, Günel C, Başak HS. The Effect of Eosinophilia Levels on the Radiological Severity of the Disease in Patients with a Nasal Polyp. Eur J Rhinol Allergy 2020; 3(2): 44-8.